December 01, 2021
+233-302-777651- 4    dgsoffice@csir.org.gh      headoffice@csir.org.gh

OBJECTIVE
This SOP is to ensure quality, a more effective and consistent ethical review mechanism of the Institutional Animal care and Use Committee (IACUC) protocol that will be dealt with so to prevent infliction of unnecessary pain and injury before, during  and after experiment on animal subjects.

GENERAL POLICY
• The Council for Scientific and Industrial research (CSIR) recognizes the moral dilemma posed by the use of sentient animals (i.e. animal which can feel sensations and experience emotions) for research, teaching or testing.  It subscribes to the ethics of only supporting studies which promise to contribute to the understanding of biology and environmental principles to the acquisition of knowledge that can reasonably be expected to benefit humans, animals and the environment.
• It recognizes that all vertebrate animals are protected by law and that it may be an offense to kill or interfere with the well-being of the animals for scientific and educational purpose without justification which is ratified by a formal process ethical review.
• It insists that animal may only be used when researcher’s best effort to find a non-sentient alternatives have been unsuccessful.
• It requires optimal standards of animal health and care to be observed to provide good quality that enhance credibility and productivity.
• It requires the ‘three R’ principles of reduction, replacement and refinement’ to be adhered to in the conduct and planning of animals studies. These uphold the principles and practice of using the most humane method of the smallest number of animal that will permit valid scientific information to be acquired.

FOR WHOM THE GUIDELINE ARE INTENDED
These guidelines apply to the use of sentient animal for research teaching and testing within CSIR and Ghana. They are applicable to all CSIR staff who are occupationally involved in the production, care and use of laboratory animal and to scientists and educators whose research, teaching and testing on is done in collaboration with CSIR or with financial other support from CSIR and its employees.

 

LABORATORY ANIMAL ETHICS

All scientists working with laboratory animals must have a deep ethical consideration for the
animals they are dealing with. From the ethical point of view it is important that such
considerations are taken care of at the individual level, at institutional level and finally at the national level.

INSTITUTIONAL BIO-SAFETY COMMITTEE (IBSC)

Institutional Bio-safety Committee (IBSC) is to be constituted in all centers engaged in genetic
engineering research & production activities. The committee will constitute the following.
• Head of Institution/his nominee
• 3 or more scientists engaged  in DNA work/molecular biology with an external expert in the relevant discipline
• A member with Medical Qualification (Bio-safety Officer) in case of work with pathogenic agent
• One member nominee by DMB

The Institutional Bio-safety Committee shall be the point for interaction within institution for
implementation of the guidelines. Any research project which is likely to have bio-hazard potential (as envisaged by the guidelines) during the execution stage or which involve the production of either micro-organisms or biologically active molecules that might cause bio-hazard should be notified to ISBC. ISBC will allow genetic engineering activity on classified organisms only at places where such work should be performed as per guidelines. Provision of suitable safe storage facility of donor, vectors, recipients and other materials involved in experimental work should be made and may be subjected to inspection on accountability.

The bio-safety functions and activity include the following:
(i) Registration of Bio-safety Committee membership composition and submission of report.
(ii) Review and clearance of project proposals failing under restricted category that meets the requirements under the guidelines on accidents, risks and on deviations if any. IACUC would make efforts to issue clearance certificate quickly on receiving the research proposals from investigators.
(iii) Tailoring bio-safety program to the level of risk assessment
(iv) Training of personnel on bio safety

PENALTIES
If any person/institution contravenes any order made by IACUC/commits a breach any
conditions imposed by committee punishable accordingly: He/She may be punishable with fine which may extended to /- and when the contravention or breach of conditions has taken place in any institutions, the person, In charge of institution shall be deemed to be guilty of the offence and shall be punishable accordingly.

CONTRACT ANIMAL EXPERIMENTS
Amendment of Rule-12, in the breeding and experiments on animal Rule 1998, this rule has been amended to allow to establishment to undertake contract research as per provision of  PCA-Act 1980, and the rules made their under.

This SOPs for the Council for Scientific and Industrial Research Ghana- Institutional Review Committee (CSIR-IRB) to govern the affairs and running of the IRB. Currently, most IRBs in the country are institutional base however, due to the absence of a National Ethical Guidelines, most IRBs adhere to International Guidelines thus the definition of a local setting may be limited to their institutional mandate of research even though most review international and multi-centered research as well.

Since CSIR has been mandated to coordinate all research activities in the country, it would be appropriate for it SOPs to have a wider coverage than limited to its 13 institutions. SOPs are written policies and procedures articulated and specified to govern IRB membership, the secretariats and the research community in carrying out their duties. To ensure efficient operation, the policies, rules, and written procedures will be reviewed periodically in the light of ongoing assessment of performance and outcomes to determine whether any revisions are needed.

Mission/Mandate
The IRB of the CSIR has been mandated for the review of studies in the fields of health and social sciences, including anthropology, sociology, and psychology according to the national act binding the CSIR. The research areas mostly under critical scrutiny include clinical trials of drugs or devices, epidemiological and parasitological studies, health care systems and delivery. Other areas include studies of social behavior, personal, opinions and attitudes.

Objective
The objective of this SOP is to contribute to effective functioning of Institutional Review Board (IRB) of the Council for Scientific and Industrial Research (CSIR), for quality and consistent ethical review mechanism of health and biomedical research.

Overview for IRB and IACUC

Research continues to play an important role in human development, especially in the area of modern medicine, where there are constant discoveries of new drugs and medical equipments for improved health. In the various fields of research, including clinical, biomedical, behavioral, as well as animal/agricultural research, there is a constant participation of human and/or animal subjects in experimental and observational studies. The involvement of human subjects in research dates back to the Second World War however, there were reports of abuses of human subjects.

In pursuit of scholarly work and research for development, the use of human and animal subjects for data collection and analysis remains relevant. The U.S. National Academy of Sciences has argued that even sophisticated computers are unable to model interactions between molecules, cells, tissues, organs, organisms, and the environment, making the use of animal for research necessary in many areas.

The Council for Scientific and Industrial Research (CSIR) Ghana is mandated to co-ordinate nation-wide research in the areas of agriculture, industrial, environment and health. The 13 component research institutions of the CSIR have the mandate to research into these four areas towards national development. The research activities and programmes of the institutes involve the development of various technologies and scientific innovations for national development. Since human and animal health is a basic component of national development, the research efforts of the CSIR in these areas are very elaborate and cannot be overemphasized, and may involve the direct or indirect use of human subjects as well as the use and care of animals and animal products. There is the need to protect both the human and animal subjects from possible abuse and other inhuman acts. 

It is very important and appropriate to establish an Institutional Review Board (IRB) and the Institutional Animal Care and Use Committees (IACUC) that will oversee and protect the human subjects and the animals used for research both in the CSIR and other institutions in Ghana. The IRB and IACUC of the CSIR will guide, approve and monitor studies involving human and animal subjects conducted by the CSIR institutes and other research institutions nationwide. Moreover, some funding agencies may require the institutionalization of IRB or/and IACUC before research funds can be approved. Most recently it is becoming increasingly difficult to publish research papers in peer-reviewed journals, without ethical clearance for studies involving human and animal subjects.

Therefore the CSIR, as a cooperate body conducting research involving both human and animal subjects would need to establish IRB and IACUC that will have oversight responsibility over all research conducted on both human and animal subjects.

In view of the above the CSIR- IRB and the IACUC was inaugurated on 31st March, 2012 under the leadership of the former Director-General, Dr. Abdulai Baba Salifu. The CSIR-IRB and the CSIR-IACUC has been mandated to review research involving human and animal subjects. This is a 10 Member board consisting of people with varied backgrounds and expertise.

AUTHORITY OF THE IRB AND IACUC

In countries where proper attention is given to the use of human and animal subjects in research, the power of the IRB and IACUC is derived from the laws established by the countries. However in the absence of such law, the CSIR as a national body responsible for co-coordinating research nationwide toke the initiative of establishing some guidelines and also promulgate the establishment of such laws.

COMPOSITION OF THE IRB/IACUC IS AS FOLLOWS:
•    Health Policy
•    Animal Breeding
•    Health Planning and Sociology
•    Medical Parasitology and Molecular Epidemiology
•    Medical practitioner
•    Bioethicist
•    Veterinarian,
•    Legal Practitioner
•    Female Social Worker
•    Community Member

The IRB/IACUC follows a structured protocol that clearly outlines terms of reference, membership, meetings and criteria for protocol reviews. The Officers of IRB comprise the Coordinator, Chair, Vice Chair and the Administrator. This body has a permanent Secretariat at CSIR-Head office which is manned by the IRB administrator. The board meets five times within a year (Every other month) and a number of expedited reviews occur as and when necessary. Protocol submitted by PIs from within CSIR should have been approved by the scientific and Technical Committee (STC) of CSIR.

© 2021 The Council for Scientific and Industrial Research (CSIR). All Rights Reserved.
cheap nba jerseys cheap jordans cheap nike air max cheap jordans for sale cheap jordan shoes